Sleep Research
Early Life Sleep Apnea Linked to Adult Hypertension: A Call for Enhanced Newborn Monitoring
This blog delves into a recently published study that uncovers a disconcerting link between sleep apnea in newborns and an elevated risk of hypertension later in life. This groundbreaking research sheds light on how intermittent hypoxia in infancy can disrupt the autonomic nervous system, which regulates involuntary physiological processes. The implications of these findings underscore the need for enhanced infant sleep monitoring and disease prevention strategies, emphasizing the vital role of companies like Neurobit in addressing these critical health challenges.
A recently published study reveals a concerning correlation between sleep apnea in newborn babies and an increased risk of hypertension later in life. This groundbreaking research, conducted by scientists at São Paulo State University (UNESP) in Brazil, offers invaluable insights into the dysregulation of the autonomic nervous system – the system controlling involuntary physiological processes – due to intermittent hypoxia in infancy. The implications of these findings call for significant improvements in infant sleep monitoring and disease prevention, highlighting the critical role companies like Neurobit play in addressing these challenges.
The research indicates that newborn babies who experience intermittent hypoxia – lower than normal levels of oxygen in body tissues due to conditions like sleep apnea – are likely to develop hypertension and respiratory problems that may persist throughout their lives. The study, published in the journal SLEEP, suggests that hypertension in such cases results from dysregulation of the autonomic nervous system, leading to overactive neurons in the sympathetic nervous system.
The study, conducted on an animal mouse model, confirmed a higher resting blood pressure in both juvenile and adult ages for subjects exposed to postnatal chronic intermittent hypoxia (pCIH) within the first two weeks of life. The researchers associated this hypertension with increased neuronal activity and increased expression of a protein called hypoxia-inducible factor 1 alpha (HIF-1α) in the medulla oblongata neurons.
These findings provide further evidence of how early life experiences can profoundly influence health outcomes in adulthood. They suggest the urgent need for enhanced sleep monitoring and breathing care in babies to prevent long-term health complications. However, a significant challenge in the field of sleep research and clinical practice is the difficulty of obtaining accurate, comprehensive, and actionable data. Conventional sleep monitoring technologies often provide limited information, are uncomfortable for the wearer, and are inaccurate and not consistently reliable.
This is where Neurobit comes in, offering innovative and scientifically-backed, and clinically validated solutions to accelerate research and improve clinical practices in sleep monitoring and analysis. By leveraging AI and deep learning, coupled with some of the largest and most diverse data sets in the world, Neurobit offers a new frontier in understanding and managing sleep health.
Neurobit Score is an advanced platform that uses AI and deep learning for accurate sleep event labeling. It offers researchers a reliable tool for studying sleep disorders like apnea and their long-term effects, helping to promote better patient outcomes.
Z3 Pulse is a wearable ECG device that provides comprehensive sleep reports and personalized guidance. This user-friendly tool can aid in the early detection and management of sleep-related health concerns, offering critical support in the effort to prevent conditions like hypertension.
Neurobit Hub is a versatile platform designed for collecting and analyzing extensive datasets. It can help researchers discover novel biomarkers and formulate sleep-centric treatment strategies, paving the way for a new era of personalized medicine.
The research linking early-life sleep apnea to adult hypertension underscores the critical importance of enhanced sleep monitoring in newborns and infants. Through innovative technologies like Neurobit Score, Z3 Pulse, and Neurobit Hub, Neurobit is poised to be at the forefront of addressing these pressing health concerns.
These tools can help clinicians diagnose and manage sleep disorders more accurately, and researchers can accelerate their studies of the effects of conditions like sleep apnea with more comprehensive results, ultimately leading to the development of better prevention and treatment strategies.
We warmly encourage researchers, clinicians, and anyone interested in promoting healthier sleep to collaborate with us in our mission to accelerate research in the field and ultimately improve sleep health.
For more information, you can reach us at Research@Neurobit.com
Citation:
Marlusa Karlen-Amarante and others, Sympathetic dysregulation induced by postnatal intermittent hypoxia, Sleep, Volume 46, Issue 5, May 2023, zsad055, https://doi.org/10.1093/sleep/zsad055
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